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Seventh Heaven is unlikely to run until the autumn after suffering a setback.
The Aidan O'Brien-trained filly had been among the leading lights for the Investec Coronation Cup at Epsom next week following her five-length stroll in the Jockey Club Stakes at Newmarket earlier this month.
However, she has been ruled out, with O'Brien expecting her to be sidelined for a lengthy period.
Last year's King George and Breeders' Cup Turf hero Highland Reel and his brother Idaho, who was third in the 2016 Derby, are instead likely to run in the Coronation Cup.
O'Brien said: "Seventh Heaven had a little bit of a setback so she probably won't be back out until the autumn.
"We are thinking that the brothers might go there (Highland Reel and Idaho)."